abstractThe fruit of Swietenia macrophylla is commonly known as ‘‘sky fruit”.The fruit, which contains flavonoidsand saponins, is processed commercially into a wide range of health foods and healthcare products.Thefruit concentrate is used traditionally to improve blood circulation and impart a healthy skin.In thispaper, we describe the isolation and structure elucidation of three new phragmalin ortho esters, namedswietephragmin H-J (1–3), and a new polyhydroxylated phragmalin, named swietemacrophine (4), fromthe leaves of S. macrophylla.The structures of the compounds were elucidated by spectroscopic methods,including HRESIMS, 1H NMR, 13C NMR, DEPT, 1H–1H COSY, HMQC, HMBC and NOESY spectra.This is thefirst report of phragmalin ortho esters and a polyhydroxylated phragmalin from this plant.Crown Copyright 2009 Published by Elsevier Ltd. All rights reserved
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