here we find that this potentiation is probably partly due to a transcriptional activation of AhR expression by PPARa ligand(WY)。this agrees with the results we obtained with PPARa KO mice,in which we did not observe any colic induction of AhR after WY treatment。analysis of human AhR promoter(Mathinspector[12])revealed one putative PPRE site located at positions 1282/1270。this PPRE seems to play an important role in AhR expression as its mutation led to the suppression of AhR promoter activation by WY and as a construction
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